Keep your powder or pills in a cold dark place, preferably with no air.If you don’t do this, 2C-B will lose potency within a few weeks or months.When you store the substance well, it will last for years or even decades. You can be sure your substance is real 2C-B if the test shows a green color. If you are a mentally stable individual who does not suffer from psychosis or have a predisposition to schizophrenia, there is virtually no way you would develop any mental illnesses because of taking the psychedelic. You may not be able to move so never trip in an unsafe environment. It also affects your 5-HT2C receptors.With that said, the only way to truly know what this psychedelic does to your brain is to try it yourself. The drug either blocks or minimally activates the 5-HT2A receptors.
- At very high doses, some have questioned their sanity.
- This realization may remain after the trip, but it may also be forgotten.
- And even with testing, you can’t be 100% sure it’s free from harmful chemicals.
- People often describe 2C-B as far more malleable, allowing them to go in and out of baseline consciousness, sometimes abruptly, even during peak effects.
Other Members of the 2C- Family
It also shows potent and efficacious anti-inflammatory effects in preclinical research. In addition to the serotonin 5-HT2 receptors, 2C-B also shows lower affinity for other serotonin receptors, such as the serotonin 5-HT1A and 5-HT1B receptors among others. In earlier studies, 2C-B was found to be a low-efficacy serotonin 5-HT2A and 5-HT2C receptor partial agonist or even antagonist.
-B vs. Mescaline
However, it is described as a “clear-headed candyflip”, with entactogenic-like effects, LSD-like effects such as visuals, but a very clear head space. In addition, it is said to produce changes in thought and time perception less frequently. Effects on average last about 6 hours and are slightly shorter than those of psilocybin. A low dose has been said to be 5 to 15 mg, a moderate dose 10 to 25 mg, and a high or strong dose 20 to 50 mg. A wider recreational dose range of 2 to 55 mg or more orally has been described as well, with a typical dose estimate of about 20 mg.
Click here for a detailed chart of safe drug combinations. It is potentially very dangerous in combination with MAOIs, tramadol, mescaline, amphetamines, cocaine, and others. Shulgin’s recommendation was to take it at the tail-end of an MDMA trip. Most but not all users report a tolerance effect from regular use (more than once every five to seven days).
Hallucinogens & Psychedelics
In one study, it had EC50Tooltip half-maximal effective concentration (EmaxTooltip maximal efficacy) values of 1.2 nM (101%) at the serotonin 5-HT2A receptor, 13 nM (97%) at the serotonin 5-HT2B receptor, and 0.63 nM (98%) at the serotonin 5-HT2C receptor. 2C-B acts as a potent partial agonist of the serotonin 5-HT2 receptors, including of the serotonin 5-HT2A and 5-HT2C receptors and to a lesser extent of the serotonin 5-HT2B receptor. Monoamine oxidase inhibitors (MAOIs) such as phenelzine, tranylcypromine, moclobemide, and selegiline may potentiate the effects of 2C-B. There is also a case report of persistent psychosis following a single dose of 2C-B.
- One of the main benefits of 2C-B over MDMA is that users usually don’t experience difficulty falling asleep after the experience.
- You can microdose with 2C-B but drugs like LSD, psilocybin, and ibogaine are more suited for this.
- The downside is that it can take hours to kick in.
- In the United States, 2C-B is classified as a Schedule I controlled substance.
Some people report experiencing gastrointestinal issues such as gas, nausea, vomiting, and diarrhea. The threshold oral dose is 2-5 mg, while a light effective dose is around 5-15 mg. 2C-B has been used as an aphrodisiac, entheogen, dance drug, ecstasy adulterant, and psychotherapeutic aid.
This means a small increase in dose will produce a large increase in effects. Its effects are considered to be somewhere between those of LSD and MDMA and vary greatly depending on the dose. 2C-B is a psychedelic drug first synthesised by Alexander Shulgin in 1974. Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume.
Experience
2C-B and related phenethylamines like mescaline have a much weaker action on this receptor. In the US, 2C-B is listed as a Schedule I drug — along with heroin, LSD, and cocaine. This led to the banning of this substance in all UN-member countries. 2C-B can eventually lead to physical addiction if used repetitively over long periods of time. This is called dependence because we depend on having the drug in our system to maintain balance.
Beyond LSD and Psilocybin is a field. This guide will take you there.
2C drugs are a group of synthetic psychedelic drugs first synthesized in the 1970s as a therapy aid. The drug’s effects increase and decrease in intensity over the course of a trip, though in large part 2C-B is much more controllable than other hallucinogens like LSD and psilocybin mushrooms. The body load physical sensation on the come-up has made me feel quite nauseous and uncomfortable a few times, but this can be mitigated by taking it on an empty stomach, having minimal alcohol beforehand and avoiding high doses.” Though research on 2C-B is scant, users also suggest that one’s tolerance to it resets after roughly 48 hours – again different to MDMA, where even taking it once every few months leaves people chasing diminishing highs with increasing amounts. Mo and the people he rubs sweaty shoulders with have more drugs available to them than previous generations, but also belong to a cohort where harm reduction knowledge is high and day-long hangovers are made untenable by weekend shifts, freelance work and the need to self-start.
The most common of these is ‘Tusi’, an onomatopoeia of the drug’s name. This article provides information on the various aspects of 2C-B, including its effects, potential risks, legal status, and much more. However, it’s still available on the regular internet as a research chemical from legal sites aimed, in theory, at scientists.
Alexander Shulgin reported a 100 mg oral dose taken without apparent harm. The toxicity and long-term health effects of recreational 2C-B use have not been studied in any scientific context, and the exact toxic dose is unknown. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive. It saw a resurgence in interest in the 2000s, with the advent of the “research chemicals”/”designer drugs” scene and darknet markets. In interviews, Shulgin repeatedly declared it his favorite psychedelic trip. 2C-B was first synthesized and tested for psychoactivity in 1974 by the American chemist and psychedelic researcher Alexander Shulgin, who was investigating novel psychedelic compounds based on the chemical structure of mescaline.
Peak effects
In the US today, 2C-B and other variants are classified as Schedule I substances by the Drug Enforcement Administration (DEA) under the Controlled Substances Act. This has also led to an increase in street prices, with many users seeking the drug out via the dark web. The easiest way to avoid risk factors is to not take the drug, though if you are planning on taking the substance there are some steps to consider in order to avoid negative reactions. Reported cases of 2C addiction are extremely rare and tend to be part of a larger pattern of substance abuse that involves addictive behaviors toward more common substances of abuse. Like other forms of hallucinogens, 2C drugs are not widely considered to be addictive as they do not cause physical or psychological dependence.
They’re using a substance to escape the way they feel or to escape a reality they deem “undesirable.” An unhealthy relationship with a substance like 2C-B would involve regular, repeated use of the substance either out of compulsion or to find a release from reality. There really isn’t such a thing as a “good drug” or a “bad drug.” Substances like 2C-B are just molecules that exist in the world around us.
A “bad” trip isn’t bad, it can actually be the most healing and insightful moment of your life! Bad trips can happen but you can prevent them by following the tips below. The drug creates a unique tingling sensation that is often combined with your body feeling extremely tired. Psychonauts describe the 2C-B experience as something in between LSD and MDMA.
Most of the responses we’ve received throughout our 2C-B survey had a positive sentiment. While there’s truth to this, it’s not perfectly accurate. The effects of 2C-B could be described as a combination of MDMA and LSD. 2C-B reached mainstream popularity sometime after 1985 when MDMA was officially banned. The qualities of 2C-B made it popular as a sex-enhancement drug in the 80s.
Mixing 2CB with other psychedelics like LSD, mescaline, or magic mushrooms can lead to much stronger hallucinations. Due to the heavily restricted status of this substance, it’s unlikely we’re going to see this research anytime in the near future. Some users, including Shulgin, have reported taking as much as 100 mg of 2C-B without serious side effects. Additionally, the few clinical trials that are available involving 2C-B have all reported the drug had little to no side effects and that the drug had a high level of safety.
Everybody should test their drugs before using them to avoid mistakenly consuming toxic alternatives. This is likely one of the main mechanisms involved with the substance’s stimulating effects. This substance is reported to influence the 2cb effects emotional response through both top-down and bottom-up cognitive processes.